Introduction


Introduction

medphy



A Concise History of Physics in Healthcare

With every advancement in science and technology, there have been curious minds trying to apply the knowledge learnt to the human body; attempting to understand the hidden secrets of nature. The following is a brief timeline of these significant milestones, that have helped shape medical physics that we know and love today:

BC Before Christ

Year Innovator Milestone
1600 Egyptians The treatment of abscesses using a fire drill, is described in the Edwin Smith Surgical Papyrus.
480 Hippocrates Wrote about the use of thermography. In his day, mud was spread over the patient’s affected areas. The parts that dried first were thought to indicate underlying organ pathology.

AD Anno Domini

Year Innovator Milestone
965 Alhazen (Ibn al-Haytham) Specialised on optics, especially the physics of vision and helped to greatly move the scientific movement forward at the time.
1508 Leonardo da Vinci Discovered the principle of the contact lens. One of the world’s first medical physicists, he was fascinated by biomechanics.
1611 Santorio Santorius Created the first clinical thermometer.
1673 Antonie van Leeuwenhoek Invented the microscope.
1680 Giovanni Borelli Related animals to machines and used mathematics to prove his theories. He is regarded as one of the founding fathers of biomechanics.
1780 Luigi Galvani Showed that a frog’s legs twitch when placed in a circuit with 2 dissimilar tools. He realised that this was a form of ‘animal electricity’ from the muscle.
1799 Alessandro Volta Invented the battery and founded the basis of electrochemistry. He discovered this by taking Luigi’s work one step forward by demonstrating that a brine-soaked cloth could be used instead of a frog’s legs.
1836 René Laennac Created the stethoscope.
1835 Michael Faraday Contributed significantly to the field of electromagnetism and started to lecture physics at St George’s university.
1850 Hermann von Helmholtz Inventor of the ophthalmoscope, to inspect the retina and other parts of the eye.
1890 Professor Reinold In this decade physics became compulsory in UK undergraduate medicine. Academic physics departments were established in medical schools across the country with, Prof. Reinold being the first lecturer of Physics at Guy’s Hospital.
1895 Wilhelm Roentgen Discovery of x-rays and circulates famous image of wife’s hand.
1896 Henri Becquerel Discovered radioactivity but also experiences an adverse effect two years later where he receive’s a burn from a piece of radium in his pocket, taking several months to heal.
1896 Thomas Edison Reports eye injuries from x-rays with further symptom reports from others later on in the year including hair loss, reddened skin, skin sloughing off, and lesions.
1898 Wilhelm Roentgen Committee of the Roentgen Society on x-ray dosage is established due to the adverse effects and injuries caused by x-rays.
1901 Henri-Alexandre Danlos Treats lupus using radium brachytherapy, which involves implanting radioactive materials directly into the affected tissue
1903 George H. Stover First radium treatment of skin cancer, he experimented on himself but sadly died early due to excessive radiation exposure.
1904 Clarence Dally First person to have reportedly died as a result of x-ray exposure.
1910 - Treatment of ringworm arises, extending its applications to the treatment of acne, skin cancers and fungal infections.
1913 - Baltimore introduces radium teletherapy, now the most common form of radiotherapy where ionising radiation is pointed at the affected area of interest.
1919 Sidney Russ Builds a teletherapy machine at Middlesex Hospital using 2.5g radium left over from the great war. It has deeper penetration than x-rays and a better depth dose than radium packs.
1923 Dr Alfred Henry Fuson Killed after falling from a roof during radio experiments.
1930 - First megavoltage x-ray system at MGH and Barts .
1934 Paterson & Parker ‘Manchester System’.
1942 - Cyclotron-produced iodine-131 is used for treatment of hyperthyroidism, four years later it is also introduced as a treatment for thyroid cancer.
1946 Mayneord & Mitchell Cobalt-60 therapy
1949 Harold Johns Betatron is invented, a device which accelerates electrons in a circular path by magnetic induction.
1950 - Medical Ultrasound
1951 William Mayneord Rectilinear scanner, an imaging device to capture emission from readiopharmaceuticals in nuclear medicine.
1953 - First linear accelerator is established in Hammersmith.
1960 Anger Gamma camera.
1964 - Technetium-99m is established as the tracer of choice.
1973 Hounsfield Computed Tomography (CT).
1973 Lauterbaur & Mansfield Magnetic Resonance Imaging (MRI).
1975 - Positron Emission Tomography (PET) is created.
2000 - Multimodality Imaging.

An interesting point to note is that physicists are not involved in clinical use, because as soon as a medical instrument/device is applied it becomes a doctors field and expertise

At the start of the twentieth century hospital physicists were mainly employed in radiotherapy and radiation protection. In the UK during 1932, only 10 - 12 hospital physicists existed and now this has grown to over 1500 physicists in 2010.

The reason for this exponential growth in numbers is the rapid advancement in new imaging and clinical measurement techniques briefly discussed above. As a result various bodies have been founded:

  • Hospital Physicists’ Association (HPA) in 1943.
  • Biological Engineering Society (BES) in 1960.
  • Institute of Physics and Engineering in Medicine (IPEM) in 1995. It is a charity, learned society and professional body with over 4000 members. They strive to ‘promote for the public benefit the advancement of physics and engineering applied to medicine and biology and to advance public education in this section’

In 2000, medical physicists and clinical engineers were regulated as ‘clinical scientists’, and became a fully-fledged healthcare profession.

The Scope of Medical Physics

With the quick progression of medical physics a lot of new areas have arisen, and now medical physicists have a large range of responsibilities ranging from a more physics based to a more engineering based:

Increased physics content
Radiotherapy physics
Radiation protection
Diagnostic radiology
Nuclear medicine
Magnetic resonance imaging
Ultrasound
Non-ionising radiation
Physiological measurement
Biomechanics
Medical electronics
Assistive technology
Medical engineering design
Medical equipment management
Increased engineering content
RADIOTHERAPY

Radiotherapy is the treatment of disease (usually cancer) using very high doses of X-ray or particle radiation. The particular role medical physics plays is to:

  • Develop new types of treatment
  • Plan for new equipment and facilities
  • Plan patient treatments
  • Check that the dose given by treatment machines is correct
  • Make sure radiation is used safely
  • Maintain treatment machines
X-Rays & CT Scans

Medical physics also has a large involvement in imaging using x-rays and computed tomography:

  • Specify new equipment to meet emerging clinical needs
  • Assess the perforce of imaging equipment
  • Maximise performance for minimum radiation dose
Nuclear Medicine

In nuclear medicine, radioactive materials can be used to obtain images of tissue function, or in larger quantities, to treat disease. With medical physics helping to:

  • Introduce new techniques into clinical practice
  • Acquire and process patient images
  • Assess the performance and safety of imaging equipment
  • Calculate radiation doses
MAGNETIC RESONANCE IMAGING MRI

MRI is structural and functional imaging using magnetic fields and radio waves instead of ionising radiation. The particular role medical physics plays is to:

  • Develop new imaging techniques
  • Plan for new equipment and facilities
  • Optimise imaging protocols for patients
  • Assess the performance and safety of imaging equipment
Clinical Engineering

Clinical engineering focus on:

  • Management of medical equipment
  • Engineering of technology for rehabilitation and assistance
  • Measurement of the physiological systems of the body
Research and Development

Medical physicists can also dedicate their time to research and development:

  • Development and application of new diagnostic and therapeutic techniques
  • A strong focus on translational research
  • Carried out in universities, industry and the NHS, often in partnership
  • Highly interdisciplinary

Some other areas of medical physics include ultrasound, radiation protection, lasers and optical imaging.

WORKING IN HEALTHCARE

There are three main fields that medical physics and clinical engineering can take you into:

1. The NHS

Most large hospitals have a ‘Medical Physics and Clinical Engineering’ department. You need:

  • A good degree in physics/engineering/related subject
  • Three year vocational training, with a salary, including an integrated MSc
  • Registration with the Health and Care Professions Council as a Clinical Scientist
  • Opportunities for advancement to consultant level posts
2. Academia

There are over 30 UK universities active in medical physics/engineering research, many with international reputations. You need:

  • Good degree in physics/engineering/related subject
  • Supervised research for PhD
  • Fundamental research that improves our understanding of biological or physical processes
  • Applied research that improves our ability to diagnose, model or treat disease
  • Publish findings in peer-reviewed journals and present results to scientific conferences
  • Teach the next generation of physicists and engineers
  • Communicate the impact of findngs to the public
3. Industry

Many leading companies have large UK facilities, and there are many specialist UK companies with innovations, for example in lasers, ultrasound and medical devices.


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Written by Tobias Whetton